soy and breast cancer survivors

Overall, they state that soy foods are both healthy and safe. Dei Cas M, Ghidoni R. Cancer Prevention and Therapy with Polyphenols: Sphingolipid-Mediated Mechanisms. BONUS! Dietary isoflavone intake and all-cause mortality in breast cancer survivors: The Breast Cancer Family Registry. Primary sources include tofu, tempeh, and edamame. Int J Cancer. Breast cancer is the most common cancer globally. Federal government websites often end in .gov or .mil. They also decrease growth and increase the self-destruction of cancer cells. . Cancer Treat Res Commun. Srikanth S, Chen Z. Phytoestrogens and cardiovascular health. Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. CMAJ. High soy isoflavone or soy-based food intake during infancy and in adulthood is associated with an increased risk of uterine fibroids in premenopausal women: a meta-analysis. Wu J, Zeng R, Huang J, et al. BY Molly Adams When it comes to eating soy foods, there are a lot of myths about what's safe for cancer survivors and patients in cancer treatment. These compounds share similarities with the hormone estrogen, which plays a role in the development of certain breast cancers. Shike M, Doane AS, Russo L, et al. Development of Nano Soy Milk through Sensory Attributes and Consumer Acceptability. Supplements may contain high doses of concentrated sources of soy. Nechuta SJ, Caan BJ, Chen WY, et al. government site. Does soy cause breast cancer? | MD Anderson Cancer Center (2019). Breast Cancer Res Treat. This means observational studies can't conclusively prove that soy protects against breast cancer. Research in Asian women has shown that soy can protect against breast cancer. Eat these foods if you enjoy them, or skip them altogether if soy isn't to your liking. Before Careers. For instance, researchers point out that the women who consumed more soy in their study also tended to have higher incomes and healthier lifestyles, factors that can also influence longevity. Is soy safe for a person with breast cancer? Academy of Nutrition and Dietetics. Studies are mixed on whether soy can relieve menopausal symptoms(1)(2)(3)(4)(5) or slow bone loss(6)(7)(8)(9). Eat Smarter, Move More! -, Ziaei S, Halaby R(2017) Dietary isoflavones and breast cancer risk. These include soy powders, soy protein powders and isoflavone supplements. This content does not have an English version. Whole soy foods that are good sources of dietary fiber provide additional benefits. The Adventist Health Study (United States). Breast Cancer Res Treat. An official website of the United States government. By clicking Agree below, you consent to use cookies if you continue to our website. This benefit of better survival odds was limited to women in the study with hormone receptor-negative cancers. This will help them manage your care and keep you safe. Still have questions? A convincing or probable judgement is strong enough to justify recommendations. Kang X, Zhang Q, Wang S, Huang X, Jin S. Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy. It is not clear how much soy a person should eat to experience any beneficial effects against breast cancer. Spagnuolo C, Russo GL, Orhan IE, et al. The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women. Dietary fibre intake and risk of breast cancer: A systematic review and meta-analysis of epidemiological studies. Soy isoflavones exhibit both selective estrogen receptor modulator activity and non-hormonal effects. Soy Food Consumption and Breast Cancer Prognosis - PMC There's also some concern that soy's estrogenic activity may interfere with tamoxifen, a drug used to prevent recurrence in women with estrogen-sensitive breast cancer. Gerhauser C. Impact of dietary gut microbial metabolites on the epigenome. Daidzein may protect against genistein-induced metastasis, and its ability to inhibit cell growth and potentiate radiation appears to be androgen-receptor-independent(60). 2010;182:1857-62. Most of the laboratory research involving soy and cancer risk has involved soys isoflavones, especially genistein and daidzein. Some tofu is high in calcium, depending on how its made. In cell and animal studies, isoflavones influence gene expression and cell signaling in ways that increase antioxidant, anti-inflammatory and carcinogen-deactivating enzymes. The summary hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using a random effects model. Use miso in soups, sauces and in marinades for meats and fish. Cancer Epidemiol Biomarkers Prev. At one time, soy seemed to be just the ticket for women: heart-healthy, good for bones, and helpful for hot flashes. There is still little data to support the use of supplements of isolated soy phytochemicals for reducing cancer risk. Clinical relevance has yet to be determined.Aromatase inhibitors: Genistein induced MCF-7 tumor cell growth and increased breast cancer-associated aromatase expression and activity in vitro, suggesting that soy-based supplements may affect treatment efficacy(54).CYP450 substrates: Soymilk and miso induced CYP3A4 in vivo, and may affect the intracellular concentration of drugs metabolized by this enzyme(67). Accordingly, we performed a systematic review and meta-analysis to explore this issue. ". (2015). Phytoestrogen intake and endometrial cancer risk. A 2016 review mentions that observational studies show that higher soy consumption is associated with an approximate 30% reduced risk of developing breast cancer in Asian women. And then there was the low rate of breast cancer in soy-consuming countries. Qin H, Lin Z, Vsquez E, Luan X, Guo F, Xu L. Nutr Res. Am JClinNutr. Subscribe to Harvard Health Online for immediate access to health news and information from Harvard Medical School. Soymilk is naturally a good source of protein; if you are substituting for milk, check the label to make sure the soymilk is fortified with calcium and vitamins D and B-12. However, the Dana-Farber Cancer Institute points out that many doctors recommend that people with hormone-sensitive cancer minimize their intake of soy protein powder supplements or soy protein isolate. Whether you are a healthcare provider, a researcher, or just someone who wants to learn more about cancer prevention, were here to help. 2022 Dec 14;14(24):6163. doi: 10.3390/cancers14246163. PLoSONE. Statements made about products have not been evaluated by the Food and Drug Administration. The consensus is that a person who has a diagnosis of breast cancer can safely consume soy products. Adverse effects of phytoestrogens on reproductive health: a report of three cases. Answering Questions About Soy and Breast Cancer - Susan G. Komen "We now have evidence that soy foods not only prevent breast cancer but also benefit women who have breast cancer," Kucuk concludes. The average daily intake of soy in the U.S. is 13 milligrams (mg), while the average daily intake in Japan is 2550 mg. However, further studies are necessary to help determine the amount of soy a person needs to eat to experience these beneficial effects. Those women who ate the highest amounts of isoflavones had a 21% lower risk of having died from any cause, compared to the women who ate the lowest amount of isoflavones. Soy and cancer risk: Our experts advice. USDA Database for the Isoflavone Content of Selected Foods, Release 2.1. Soy food intake and breast cancer survival. Messina M, Rogero MM, Fisberg M, Waitzberg D. Health impact of childhood and adolescent soy consumption. Keep in mind it is high in sodium. However, isoflavones bind to estrogen receptors differently and function differently than estrogen. Managing symptoms caused by menopause (permanent end of menstrual cycles), such as hot flashes, Allergic reactions, such as rashes or hives. Perspective: Physiologic Importance of Short-Chain Fatty Acids from Nondigestible Carbohydrate Fermentation. Conclusion: Messina, M. (2016). 2023 Feb 15;152(4):616-634. doi: 10.1002/ijc.34321. Overall, randomized controlled intervention trials in premenopausal and postmenopausal women without cancer testing have found no clear beneficial or harmful effects on markers of breast cancer risk such as hormone levels, markers of breast cell growth, or breast density. Epub 2009 Feb 17. 2011;125:315-23. Breast cancer; Breast cancer specific survival; Overall survival; Soy isoflavone. Its salty, savory flavor makes miso a popular base for soups. The .gov means its official. Amounts of isoflavones consumed were above those recognized as safe which is 100 mg/day underscoring the point that more is not necessarily better. That makes it challenging for U.S. observational studies to compare how the highest versus lowest intake links to cancer risk. This website uses cookies. AICR Blog. She says it's not clear what the results in terms of long-term survival would be if women in the U.S. consumed a lot more. However, genistein induces estrogen-dependent MCF-7 tumor cell growth and increases breast cancer-associated aromatase expression/activity, suggesting that soy-based supplements may affect aromatase inhibitor efficacy(54). 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A variety of health benefits, including protection against breast cancer, have been attributed to soy food consumption, primarily because of the soybean isoflavones (genistein, daidzein, glycitein). But there are important differences. To continue reading this article, you must log in. This site needs JavaScript to work properly. Potential modulation on P-glycoprotein and CYP3A by soymilk and miso: in vivo and ex-vivo studies. MNT is the registered trade mark of Healthline Media. Products containing soy as a food additive in the form of soy lecithin and soy oil are also generally safe for people living with breast cancer. Lets compare: 85178 mg total isoflavone / 100g serving (depending on country of origin). Clinical relevance is not known.UGT substrates: Soy modulates UGT enzymes in vitro and can increase the side effects of drugs metabolized by them(68). Background: Early research indicated that soy protein could lower LDL (bad) cholesterol. PMCID: PMC2874068 DOI: 10.1001/jama.2009.1783 Abstract Context: Soy foods are rich in isoflavones, a major group of phytoestrogens that have been hypothesized to reduce the risk of breast cancer. Soy food consumption and breast cancer prognosis. Clinical effects of a standardized soy extract in postmenopausal women: a pilot study. Aune D, Chan DS, Greenwood DC, et al. New research finds eating soy milk, edamame and tofu does not have harmful effects for women with breast cancer, as some have worried. Rebello CJ, Greenway FL, Finley JW. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. Examples of a standard serving are 1/3 cup (about 3 oz.) And although some studies suggest that it may protect against breast cancer, other research has found that isoflavones (a component of soy that binds to estrogen receptors) can spur the growth of breast cancer cells in test tubes and animals. Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. This means that different soy supplements may contain higher or lower concentrations of soy-based products. Hypogonadism and erectile dysfunction associated with soy product consumption. The Effects of Soy Supplementation on Gene Expression in Breast Cancer: A Randomized Placebo-Controlled Study. Isoflavones, especially genistein and daidzein, are the focus of most of the laboratory research involving soy and cancer risk. Front Plant Sci. and transmitted securely. 8600 Rockville Pike Mller M, Canfora EE, Blaak EE. The analysis found that women who consumed 10 mg or more of soy daily had a 25% reduced risk of cancer recurrence compared to those who consumed less than 4 mg of soy daily. AICR Cancer Prevention Recommendations as a Path to Diet Quality, Added Sugars Added Risk? The .gov means its official. Soy Food Intake and Biomarkers of Breast Cancer Risk: Possible Difference in Asian Women? The Best Diets for Cognitive Fitness, is yours absolutely FREE when you sign up to receive Health Alerts from Harvard Medical School. The American Institute for Cancer Research is a nonprofit charity designated as tax-exempt under Section 501(c)3 by the Internal Revenue Service. The human body metabolizes isoflavone differently thanrodents. Wu AH, Spicer D, Garcia A, et al. Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women. University of California San Francisco Health, https://blog.komen.org/blog/komen-perspectives-answering-questions-about-soy-and-breast-cancer/, https://www.nhs.uk/conditions/breast-cancer/causes/, https://www.wcrf.org/wp-content/uploads/2021/02/Summary-of-Third-Expert-Report-2018.pdfv, https://pubmed.ncbi.nlm.nih.gov/17855484/, https://www.dana-farber.org/for-patients-and-families/care-and-treatment/support-services-and-amenities/nutrition-services/faqs/soy-and-cancer/, https://pubmed.ncbi.nlm.nih.gov/27161216/, https://academic.oup.com/ajcn/article/96/1/123/4571417, https://pubmed.ncbi.nlm.nih.gov/30382332/, https://www.oncologynutrition.org/erfc/healthy-nutrition-now/foods/soy-and-breast-cancer, https://www.oncolink.org/support/nutrition-and-cancer/during-and-after-treatment/soy-and-breast-cancer, https://www.cancer.org/latest-news/soy-and-cancer-risk-our-experts-advice.html, https://www.ucsfhealth.org/education/soy-protein-content-of-foods, https://www.breastcancer.org/symptoms/understand_bc/statistics, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590054/, Exercise may raise stroke risk for people with moderate to severe blocked arteries, Social isolation, loneliness linked to increased risk of all-cause mortality, Intermittent fasting and traditional calorie counting about equal for weight loss, Whole-food, plant-based diet linked to type 2 diabetes remission, How 'natural killer' cells may be a new approach to treating neuropathic pain. A person should speak with a doctor about their risk factors before starting a soy supplement. However, soy pills and isoflavone-enriched powders should be avoided. Overall, the data are not impressive that the adult consumption of soy affects the risk of developing breast cancer or that soy consumption affects the survival of breast cancer patients. Soy is a type of legume that contains plant compounds called phytoestrogens. It also demonstrated an anti-minichromosome maintenance effect, a gene family upregulated in various cancers and considered a promising drug target(52). However, most studies have not shown effects on PSA. Jenie RI, Amalina ND, Ilmawati GPN, Utomo RY, Ikawati M, Khumaira A, Kato JY, Meiyanto E. Adv Pharm Bull. Justin Sullivan/Getty Images This is important because soy has long been a part of many Asian cuisines, but it is a relatively new introduction to the American diet. Studies among prostate cancer survivors indicate that eating soy foods may lower PSA levels. 2021;27:100350. doi: 10.1016/j.ctarc.2021.100350. More recently, processed soy protein has been added to a variety of foods, such as frozen meals, soups, protein powder drinks, and snack bars. From diagnosis to treatment, our experts provide the care and support you need, when you need it. Bishop KS, Ferguson LR. Talk with your healthcare provider if youre takingaromatase inhibitors. The gut microbiota at the intersection of diet and human health. 2022 Nov 28;68(11):1487-1489. doi: 10.1590/1806-9282.2EDITR11. -. Meta-analysis of soy intake and breast cancer risk. In fact, for some breast cancer survivors, soy consumption was found to be tied to longer life. One intervention using a supplement combining soy isoflavones and some other potentially protective compounds reported improved PSA. Eating primary sources of soy may have a positive impact on breast cancer prevention and survival. Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial. soy nuts. However, in a patient-derived prostate cancer xenograft model, increased proliferation and metastasis in genistein-treated groups were linked to enhanced activities of tyrosine kinases, EGFR, and its downstream Src(45). Soy also contains significant amounts of isoflavones including genistein, daidzein, and glycitein. Some benefits ascribed to dietary isoflavones may depend on early life exposure, thereby impacting gene expression at the epigenetic level(55). Metastatic breast cancer refers to breast cancer that has spread to other parts of the body. With consumption only lasting from 7 to 30 days and many unknowns about other gene changes, theclinical significance of the study is unclear. Anyone who is considering making significant changes to their diet should speak with a doctor before doing so. Bethesda, MD 20894, Web Policies
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