does grapefruit affect alcohol metabolismdoes grapefruit affect alcohol metabolism

Interactions with grapefruit can occur with common and important medications - such as those that lower cholesterol, treat high blood pressure, or even those that fight cancer. This can lead to enhanced side effects or lower drug effectiveness. Examples of some of the most common grapefruit or grapefruit juice drug interactions that can occur include: There are numerous other drug interactions with grapefruit and grapefruit juice; this is not a complete list. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (, nonalcoholic beverages, alcohol metabolism, hepatoprotection, harmful impact. National Library of Medicine FDA Consumer Health Articles. The use of grapefruit juice with a few specific drugs (eg, fexofenadine, digoxin) may lower plasma drug concentrations by inhibiting drug absorption catalyzed by the organic anion transporting polypeptide (OATP). Two out of the 20 kinds of beverages were not recommended to consume after alcohol drinking. A study has demonstrated the alkalescent electrolyzed-reduced water has an effect of alcohol detoxification through its antioxidant capacity and has potentiality for relief of ethanol-induced hangover symptoms in Sprague-Dawley rats, such as lowering the levels of AST and ALT in serum, significantly increased the levels of glutathione, glutathione peroxidase, glutathione-S-transferase, Cu/Zn-superoxide dismutase, and catalase in liver [23]. Am Fam Physician. An official website of the United States government. Soda water, green tea, and honey chrysanthemum tea are recommended to consume accompanied with alcohol drinking due to their capacities of accelerating ethanol metabolism and preventing liver injuries caused by alcohol. Alcohol intake and bone status in elderly Japanese men: Baseline data from the Fujiwara-kyo osteoporosis risk in men (FORMEN) study. It is important to check for potential drug interactions. Dr. Richard B. Kim, a professor of medicine and pharmacology at Vanderbilt University, agreed that the interaction was a serious health concern in some patients. Research advances in ethanol metabolism. It also affects some retroviral medications, anti-seizure and anti-anxiety . Fresh orange juice significantly increased the content of acetaldehyde in blood as well as the activities of AST and ALT, and remarkably inhibited the activity of ALDH. Grapefruit juice-felodipine interaction increases with increasing frequency and amount of grapefruit juice ingestion, hence it has been determined that an interval of 2-3 days between . Liddell holds a Doctor of Philosophy in biological and biomedical sciences from Harvard University. Zimatkin S.M., Pronko S.P., Vasiliou V., Gonzalez F.J., Deitrich R.A. Enzymatic mechanisms of ethanol oxidation in the brain. ); moc.621@usyspdux (D.-P.X. What are the risks vs. benefits of medications? Drug Metab Dispos. Grapefruit Juice and Some Drugs Don't Mix. Effects of the 20 selected beverages on serum AST and ALT activities in serum. Grapefruit juice should not be consumed by patients taking certain calcium channel blockers, statins and immunosuppressants. While Dr. Bailey suggests avoiding grapefruit juice entirely when taking medicine, some experts say the effect of the juice should not be exaggerated. Nonalcoholic beverages are usually consumed accompanying alcoholic drinks, and their effects on alcohol metabolism are unclear in vivo. They were housed in a pathogen-free barrier facility accredited by the Association for Assessment and Accreditation of Laboratory Animal Care and had free access to food and tap water. Briguglio M, Hrelia S, Malaguti M, Serpe L, Canaparo R, Dell'Osso B, Galentino R, De Michele S, Dina CZ, Porta M, Banfi G. Pharmaceutics. 2004 Jun;75(6):569-79. doi: 10.1016/j.clpt.2004.02.007. Potential interaction between pomegranate juice and warfarin. Do not drink alcohol while you are taking Wellbutrin 1. This work was supported by the National Natural Science Foundation of China (No. As a result, drugs that are normally broken down by this enzyme remain active in the body for longer periods of time. Effects of Beverages on Alcohol Metabolism: Potential Health Benefits And then theres all your other prescriptions. The manufacturers of cyclosporine (Sandimmune, Neoral) and simvastatin (Zocor) have gone so far as to place warnings on their drugs package inserts.25,31,32. Inhibitory Effects of Fruit Juices on Cytochrome P450 2C9 Activity in Vitro, The grapefruit: an old wine in a new glass? As can be seen in Table 4, the treatment of soda water, honey chrysanthemum tea, he qi zheng herbal infusion and semen coicis herbal infusion significantly prevented the increase of the MDA level in liver. Increased plasma concentration may cause headaches, gastrointestinal complaints, hepatic inflammation, and myopathies (e.g., rhabdomyolysis). Ingestion of green tea with solid contents 2.0 g/L significantly increased reducing power in plasma [26,27]. 2023 Minute Media - All Rights Reserved. How do I remember to take my medications? Epidemiological studies have shown low-to-moderate alcohol consumption is beneficial for several cardiovascular diseases and other diseases such as diabetes mellitus and pancreatitis [1,2,3]. 2022 May 26;9:907595. doi: 10.3389/fnut.2022.907595. Glaeser H, Bailey DG, Dresser GK, Gregor JC, Schwarz UI, McGrath JS, Jolicoeur E, Lee W, Leake BF, Tirona RG, Kim RB. Disulfiram, an aldehyde dehydrogenase inhibitor, was approved by the FDA in 1951 as an aversive therapy for treating alcohol dependence. The levels of aspartate aminotransferase (AST) and alanine transaminase (ALT) in serum as well as the levels of malonaldehyde (MDA) and superoxide dismutase (SOD) in liver were measured to reflect the alcohol-induced liver injury. The grapefruit (Citrus x paradisi) and its juice contain chemicals that interfere with CYP3A4 and keep it from doing its job properly. Careers. Evidence Based Grapefruit Warning: It Can Interact with Common Medications Grapefruit and its close relatives can increase the blood levels of certain drugs and cause serious side effects.. The enzymes that are affected are 3A4, 1A2 and 2A6. An article published in Hospital Pharmacy found 23 drinks with grapefruit in them, five of them which didn't have the word grapefruit in the name! Grapefruit interacts with certain medications by inhibiting an important enzyme that is responsible for metabolizing, or breaking down, the drug in the body. Before you hit the bar, though, it should be noted that alcohol can deter your fitness goals, not because of its chemical makeup but rather the vehicle that carries it (beer, wine, etc.). In addition, jasmine tea decreased the level of AST, and fructus cannabis herbal infusion decreased the level of ALT, suggesting that they might provide some protection from liver injury caused by alcohol. **: Difference between the control and normal group was statistically significant (p < 0.05). Fooling around with grapefruit juice is not a good idea.". Review of the in vitro, preclinical and clinical evidence. Huang C., Zhan J., Liu Y.J., Li D.J., Wang S.Q., He Q.Q. Accessed May 18, 2022 at DOI. Will that night out inhibit all of the progress Ive been making at the gym and with my diet? If you drink grapefruit juice, always have your pharmacist run a drug interaction check with your medications to rule out an interaction before you combine them. Enzymes in the intestines break down many types of medicines, including macrolide antibiotics. sharing sensitive information, make sure youre on a federal With that said, the truth is that you can, in fact, drink alcohol without derailing your fitness goals. Eur J Drug Metab Pharmacokinet. No, according to Dr. Bailey. The effects of grapefruit on weight and insulin resistance - PubMed The content of acetaldehyde in blood was decreased when ALDH activity was boosted; on the contrary, the content of acetaldehyde in blood was increased when ALDH activity was inhibited by beverages. We comply with the HONcode standard for trustworthy health information. They were testing the effects of drinking alcohol on a medicine called Plendil. Grapefruit juice decreases the activity of the cytochrome P450 3A4 (CYP3A4) enzymes that are responsible for breaking down many drugs and toxins. You can also consult your doctor about alcohol consumption and metoprolol if you have questions. Krga I, Corral-Jara KF, Barber-Chamoux N, Dubray C, Morand C, Milenkovic D. Front Nutr. Bookshelf When the ALDH activity was inhibited, the speed of acetaldehyde oxidative into acetic acid was slowed, thus the acetaldehyde could be accumulated in the body system, leading to serious hangover symptoms. These beverages could disturb the metabolism of ethanol and accumulated toxic acetaldehyde in blood, causing harmful effects on human health. Alcohol is eliminated through its metabolic degradation via multiple enzymatic pathways and non-enzymatic pathways. Free radicals derived from oxygen were an important factor to liver injury. government site. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. In this study, the effects of 20 nonalcoholic beverages on alcohol metabolism and liver injury caused by alcohol were evaluated in mice. This process happens rather quickly (unless youre really hitting the bottle), so this delay of nutrient absorption is actually pretty overblown. Grapefruit juice affects how drugs are changed (metabolized) in the body for eventual elimination and can alter the amount of drug in your blood. And lest we forget, alcohol itself does contain calories (7 per gram, which is less than fat but more than carbs and protein). Grapefruit juice should not be consumed by patients taking certain calcium channel blockers, statins and immunosuppressants. This is one of the most well-known orange juice drug interactions and one of the first ones identified. Three (soda water, honey chrysanthemum tea and green tea) out of the 20 kinds of beverages were recommended to consume after excessive alcohol drinking due to their protection from alcohol-induced injuries. Effects of the 20 selected beverages on ADH and ALDH activity in liver. 2018 Apr;26(2S):S61-S71. 2005 May;33(5):644-8. Can I Drink Grapefruit Juice With Wellbutrin? | Healthfully Some patients experience suicidal thoughts while taking Wellbutrin 1. As a result, drugs that are normally broken down by this enzyme remain active in the body for longer periods of time. All procedures involving laboratory animal use were approved by the Institutional Animal Care and Use Committee of Sun Yat-Sen University. Front Mol Biosci. If in doubt about your antibiotic and potential interaction with grapefruit, talk with your pharmacist or prescribing provider. Michael J. Ermarth for the U.S. Food and Drug Administration. The in vitro assay involved analysis of sertraline metabolism by CYP3A4 using CYP3A4-expressed human beta-lymphoblast microsomes. Grapefruit: Beware of dangerous medication interactions - Mayo Clinic This enzyme metabolizes many drugs, and toxins as well, into substances that are less potent or more easily excreted or both. Kunming mice were orally fed with alcohol (52%, v/v) and beverages. Does this mean a person could reduce the amount of medicine required simply by drinking grapefruit juice? This is because unlike carbs, protein, and fat, your body isnt equipped with a storage capacity for alcohol, so when you drink, getting it out of your system is your bodys immediate priority. The https:// ensures that you are connecting to the In addition, red bull and fresh orange juice notably increased the level of ALT, while green tea, honey chrysanthemum tea, fructus cannabis herbal infusion, and soda water dramatically lowered the level of ALT in serum. Studies have confirmed that combining energy drinks (such as red bull) with alcohol could mask the signs of alcohol intoxication, resulting in greater levels of alcohol intake, dehydration, more severe and prolonged hangovers, and alcohol poisoning [29,30]. Their effects on alcohol metabolism and potential health benefits and harmful impacts when accompanied with alcohol consumption were systematically evaluated using mice as test models. There was also a significant reduction in 2-hour post-glucose insulin level in the grapefruit group compared with placebo. Nutraceutical strategies for ameliorating the toxic effects of alcohol. Seizures may occur and are more common in patients taking other medications with Wellbutrin 1. Green tea could significantly decrease the activities of AST and ALT, increase the activity of ADH. The studies have confirmed that several factors may affect the metabolism of ethanol, such as food and drink consumption, genetic polymorphism of ethanol-metabolizing enzymes, or medications which interfere with the activity of the metabolizing enzymes and/or with the absorption of ethanol [12,13]. Grapefruit juice-drug interactions. Please enable it to take advantage of the complete set of features! Grapefruit juice interferes with the ability of CYP 3A4 to do that, increasing the potency of a drug by letting more of it enter the bloodstream, in effect producing an excessive dose.. "The problem is the unpredictability of the effect," he said. Acetaldehyde and parkinsonism: Role of CYP450 2E1. Accessed March 30, 2019. But why is this so important? Finding why juice had that effect was the next question. Tea (Camellia sinensis) is the most consumed beverage in China. The injection port temperature was 220 C, while the flame ionization detector (FID) temperature was 250 C. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made. The grapefruit ( Citrus x paradisi) and its juice contain chemicals that interfere with CYP3A4 and keep it from doing its job properly. Swift R.M. Armstrong C. ACOG guidelines on psychiatric medication use during pregnancy and lactation. Elevated international normalized ratio with the consumption of All of the other chemicals and solvents used in this study were of analytical grade. Zhao J., Chen H., Li Y. The levels of blood alcohol and acetaldehyde are rapidly elevated 2 h after alcohol consumption when compared with the normal group (untreated group) (Table 1). These alternative drugs may be substituted if a patient experiences or is at risk of a grapefruit-drug interaction. Red bull could significantly increase the concentration of acetaldehyde in blood and the activity of ALT. However, the fruit has been shown to affect the metabolism of many medications, increasing the risk of toxicity and adverse effects. This is because unlike carbs, protein, and fat, your . The liver damage was evaluated by measuring the activities of AST and ALT in serum. "The only thing that covered the taste was grapefruit juice.". FOIA The ADH metabolized the bulk of ethanol within the liver, and the others also contributed to the production of acetaldehyde from ethanol oxidation. 2015 Sep 8;10:1457-66. doi: 10.2147/CIA.S87466. Insulin resistance was improved with fresh grapefruit. Soda water, honey chrysanthemum tea, he qi zheng herbal infusion, and semen coicis herbal infusion significantly decreased the level of MDA in liver, suggesting that these beverages could attenuate alcohol-induced oxidative stress. In addition, alcohol use disorder caused by long term alcohol drinking is a detrimental disease that affects a large population [7]. In addition, the mechanism of a beverage leading to acetaldehyde accumulation was similar to that of a drug therapy for alcohol dependence. Increased concentrations are primarily mediated by chemicals in grapefruit juice, which inhibit the CYP 3A4 drug-metabolizing enzyme in the small intestines. Accessed May 18, 2022 at. Protective effect of bicyclol on acute alcohol-induced liver injury in mice. For treatment groups, ban sha herbal infusion, sprite, and fresh orange juice obviously increased the level of AST, while green tea, honey chrysanthemum tea, jasmine tea, and soda water markedly decreased the level of AST in serum. Medically reviewed by Leigh Ann Anderson, PharmD. Accessed May 18, 2022 at, Bailey DG, Malcolm J, Arnold O, et al. The treatment of honey citron tea significantly decreased the concentration of ethanol in blood of intoxicated mice, and increased the acetaldehyde level in blood significantly, which means that honey citron tea could accelerate the speed of first pass of ethanol metabolism. It is recommended that fexofenadine be taken with water, and not fruit juice. In this study, 20 non-alcoholic beverages, including herb infusions, tea, and carbonated beverages, which are consumed frequently in China, were selected. A patient may choose to exclude grapefruit from his or her diet and substitute other fruits, including any other citrus.3 However, if the patient wishes to continue to consume grapefruit products, an alternate medication that does not have the potential to interact with grapefruit may be prescribed. Horn J, Hansten P. Fruit Juice Interactions. The concentrations of ethanol and acetaldehyde in blood as well as the activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in liver were assessed to indicate alcohol metabolism. Emran TB, Islam F, Nath N, Sutradhar H, Das R, Mitra S, Alshahrani MM, Alhasaniah AH, Sharma R. Life (Basel). Atorvastatin (Lipitor), lovastatin (Mevacor), simvastatin (Zocor). Green tea possessed a strong antioxidant capacity owing to abundant of polyphenols, such as catechin, epicatechin and gallate [24]. Eating grapefruit or drinking grapefruit juice can affect antibiotic metabolism for up to 72 hours. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 's, like Prozac, which are used to treat depression. May cause drowsiness. Do not drink alcoholic beverages while taking this medication. Most warnings on prescription bottles are pretty easy to understand. A secondary analysis of those with the metabolic syndrome in the four treatment groups demonstrated a significantly greater weight loss in the grapefruit, grapefruit capsule, and grapefruit juice groups compared with placebo (P < .02). PMC Epidemiological studies have shown low-to-moderate alcohol consumption is beneficial for several cardiovascular diseases and other diseases such as diabetes mellitus and pancreatitis [1,2,3].However, excessive drinking does much harm to human health, causing hangover symptoms, alcoholic hepatitis, cirrhosis, and . FDA. 2014B020205002), and the Hundred-Talents Scheme of Sun Yat-Sen University. Grapefruit or grapefruit juice can alter enzymes in the body and affect how drugs are changed in the body before they are eliminated. When grapefruit juice is consumed, the enzymes ability to break down the drug for elimination is decreased. Macrolides may be prescribed for respiratory infections, such as pneumonia, bronchitis and sinusitis. GlaxoSmithKline. For most medications, orange juice, apple juice, or grape juice can be consumed instead of grapefruit juice without any concern for an interaction. Updated December 2018. *: Difference between the sample and the control was statistically significant (p < 0.05). Its a question weve all had at some point in our wellness journey: Can I have a drink every once in a while and still stay fit? It also affects some retroviral medications, anti-seizure and anti-anxiety drugs. Grapefruit juice-nifedipine interaction: possible involvement of several mechanisms. The site is secure. Clin Pharmacol Ther. Common drugs that interact with grapefruit juice. Half of a fresh grapefruit eaten before meals was associated with significant weight loss. This study has supplied new information on the effects of the beverages on alcohol metabolism for nutritionists and the general public, and further studies on the precise compounds and mechanisms responsible for the action is needed. 2006 Apr;34(4):521-3. Liver tissue samples were taken from the left liver lobe, and then were homogenized in ice-cold 0.9% NaCl solution. "People didn't believe us," Dr. Bailey said. An official website of the United States government. Lindahl R., Evces S. Changes in aldehyde dehydrogenase activity during diethylnitrosamine-initiated rat hepatocarcinogenesis. Clin Pharmacol Ther. Unauthorized use of these marks is strictly prohibited. Wellbutrin (buproprion hydrochloride) tablets prescribing information. Grapefruit juice does not affect the metabolism of Wellbutrin but it does interact with a variety of other medications for various conditions 1. Numerous studies now show the interaction of grapefruit juice with many widely used medicines. Fang Wang, Sha Li, and Hua-Bin Li conceived and designed the experiments; Fang Wang, Yu-Jie Zhang, Ya Li, Yue Zhou, Tong Zhou, Jie Zheng, Jiao-Jiao Zhang, and Dong-Ping Xu performed the experiments; Fang Wang analyzed the data and wrote the paper; Sha Li and Hua-Bin Li revised the paper. Clin Pharmacol Ther. 2023 May 5;14:1174545. doi: 10.3389/fendo.2023.1174545. Side effects can range from abnormal heart rhythms, stomach bleeding, muscle pain, muscle breakdown, kidney damage, low blood pressure, difficulty breathing, sedation, and dizziness. Inclusion in an NLM database does not imply endorsement of, or agreement with, There are equally effective alternatives to these drug classes that do not have the potential to interact with grapefruit. Grapefruit Warning: It Can Interact with Common Medications - Healthline But blood levels of the drug went up significantly in the control group that drank just grapefruit juice, without alcohol. This increases your chance of experiencing side effects from the medication. Fexofenadine (Allegra), a popular non-drowsy antihistamine available over-the-counter (OTC) or by prescription, can interact not only with grapefruit juice, but also with apple and orange juice. Ethanol, acetaldehyde, Tris, pyrazole, acetic acid, sodium chloride, and chloral hydrate were purchased from Tianjin Chemical Factory (Tianjin, China). Other fruits and fruit juices may also need to be curtailed. When you drink, your body essentially puts all the other foods youve consumed on the back-burner, and devotes itself to metabolizing the alcohol first. Before But there are some cases in which it's significant.". Bailey DG, Dresser G, Arnold M, et al. Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint. ), 2School of Chinese Medicine, The University of Hong Kong, Hong Kong 999077, China; moc.361@8030lsahsil, 3South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou 510006, China. p < 0.05 was considered significantly different. Seville oranges (the kind often used in marmalade) and tangelos are CYP3A4 blockers, too. In brief, 0.1 mL of 0.3 mol/L ethanol and 2.8 mL 0.0021 mol/L NAD+ (prepared by 0.1 mol/L Tirs-HCl buffer, pH 7) were mixed at 25 C, and then 0.1 mL of the liver supernatant was added to initiate the reaction. If you have questions about how your prescriptions will interact with a specific food or other drugs or supplements, talk to your doctor or pharmacist. Common Grapefruit Juice Drug Interactions - Drugs.com The mice were randomly divided into different groups with five mice in each group, including the normal group (untreated group), control group, and treatment groups. The homogenate (10%, w/v) was centrifuged at 4500 g for 10 min and the supernatant was used for biochemical analysis. Modern approaches to dietary]. Depending on the medication, it can either cause your body to take in and retain too much of the drug, leading to a potential overdose, or not enough, rendering your medication useless. government site. Bookshelf A shot of clear liquor will run you about 80 to 90 calories on average, while fruity drinks or heavy beers like IPAs can exceed 200. Li A.N., Li S., Zhang Y.J., Xu X.R., Chen Y.M., Li H.B. The effects of grapefruit juice on certain medications can last for over 24 hours. Assessment of liver function could be performed by measuring the activities of serum enzymes. In comparison with normal group, there was a significant increase in the level of MDA in control group, suggesting the development of peroxidation in liver tissue. Problems arise because chemicals in the fruit can interfere with the enzymes that break down (metabolize) the medication in your digestive system. or other medication to be taken at a time when the grapefruit juice would have mostly been metabolized.". Generally, effects of the beverages on alcohol metabolism and alcohol-induced liver injury were very different. Health care providers should be informed of which medications patients are taking, including any prescription and OTC drugs, herbal supplements and vitamins. Unable to load your collection due to an error, Unable to load your delegates due to an error. Accessed May 18, 2022 at ; DOI: Kim H, Yoon YJ, Shon JH, et al. They might be potential dietary supplement for the alleviation of harmful effects from alcohol consumption. Wellbutrin Prescribing Information. If you typically consume alcohol, talk to your doctor before beginning the medication. Grapefruit juice and drug interactions. Exploring mechanisms of this 2002 Jan;71(1):21-9. If you enjoy grapefruit juice, always ask your doctor or pharmacist about possible interactions before beginning a new medication. Grapefruit Juice Flavanones Modulate the Expression of Genes Regulating Inflammation, Cell Interactions and Vascular Function in Peripheral Blood Mononuclear Cells of Postmenopausal Women. Other reactions may occur -- it depends on the drug and the levels of the drug in the blood. Its no secret that alcohol lowers your inhibitions and impairs your ability to make rational decisions. If an interaction is found to occur, it may be possible that an alternative medication can be prescribed and the interaction can be avoided. Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human small intestine. The levels of serum ALT and AST were determined by the Jiancheng Bioengineering Institute reagents (Nanjing, China), following the instructions of the manufacturer. Digoxin (Lanoxin), diltiazem (Cardizem), verapamil (Calan), Amlodipine (Norvasc), diltiazem (Cardizem), verapamil (Calan), Fluvastatin (Lescol), pravastatin (Pravachol), rosuvastatin (Crestor), Fibric acids, nicotinic acid, or bile acid sequestrants, Amprenavir (Agenerase), atazanavir (Reyataz), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir/ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir), The importance of clearly understanding possible interactions between drugs and grapefruit products is becoming more evident. So they used it in their experiment, expecting the grapefruit juice to be irrelevant to their results. Accessibility Increased plasma concentration may lead to flushing, peripheral edema, headaches, tachycardia, symptomatic hypotension, and myocardial infarction in rare cases. NAD+ was purchased from Sigma Chemical Co. (St. Louis, MI, USA). 2019 Jan 4;11(1):e3827. and transmitted securely. Detection kits were purchased from Jiancheng Institute of Biotechnology (Nanjing, China) and Beyotime Institute of Biotechnology (Shanghai, China). The formation of acetaldehyde in alcohol metabolism is associated with an increase in reactive oxygen species formation, leading to the development of oxidative stress in the liver. 2004;6(4):159-166. J Med Food. You can stop eating grapefruit for the duration of your medication course. Accessed May 18, 2022 at pharmacytimes.com/publications/issue/2005/2005-12/2005-12-5042, Mayo Clinic. Chemicals in grapefruit and grapefruit juice block these enzymes and disrupt their function. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. Although the mechanism of this weight loss is unknown it would appear reasonable to include grapefruit in a weight reduction diet. These 11 Medications Interact With Grapefruit Juice - GoodRx Careers. 2013 Dec;38(4):223-9. Bonar E.E., Cunningham R.M., Polshkova S., Chermack S.T., Blow F.C., Walton M.A. 1Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China; ten.haey@gnefgnissim (F.W. Matt Scheetz is a brand strategist at mindbodygreen. Six hours later, the mice were anesthetized by injecting intraperitoneally 10% chloral hydrate (350 mg/kg body weight) [20,21,36]. The dangers of grapefruit juice - The New York Times Ibrance (palbociclib). Pomegranate juice (from a berry) is a delicious fruit that is full of antioxidants and vitamin C. However, this "superfood" has an interaction with the breast cancer treatment ribociclib (Kisqali), as noted in product labeling.