Soy might lower the risk of other cancers. The take home message regarding soy and cancer is that eating tofu stir-fry, an edamame appetizer or having unsweetened soy milk as a replacement for dairy is safe for cancer survivors. Can Eating Soy Cause Breast Cancer? | Cancer.Net due to their concentrated nature. All rights reserved. The short and The association between tofu intake and breast cancer incidence has been considered in several studies, with conflicting results. Theres a lot of conflicting information going around about soy: Is it healthy? No one would ever imagine that fact that tofu can be linked to breast cancer. Prostate cancer (PCa) is the second most commonly diagnosed cancer in men, accounting for 15% of all cancers in men worldwide. Should we be consuming soy milk? Feeding infants with formula supplemented with soy fiber seems to reduce diarrhea. When studies reported results separately by menopause or estrogen receptor (ER) status, both risk estimates were included separately in the analyses. An official website of the United States government. So far, the evidence does not point to any dangers from eating soy in people, and the health benefits appear to outweigh any potential risk. Isoflavones: Definition, Benefits, and Risks - Verywell Health These may help protect against some cancers, heart disease, and osteoporosis. 10. Do soy foods increase cancer risk? Fig 1 demonstrated the detailed process of study selection from the initial search to final inclusion. Medical News Today only shows you brands and products that we stand behind. Isolated soy protein consumption reduces urinary albumin excretion and improves the serum lipid profile in men with type 2 diabetes mellitus and nephropathy. Isoflavone and Soyfood Intake and Colorectal Cancer Risk: A Case - PLOS Tofu (bean curd), a popular food derived from soy, have long been a staple of Asian diets. Some of the misunderstandings come from the fact that studies in people and studies in animals may show different results. Hirose K, Takezaki T, Hamajima N, Miura S, Tajima K. Dietary factors protective against breast cancer in Japanese premenopausal and postmenopausal women. All these studies were considered of high quality. A further concern with a high soy intake is that the phytoestrogen in soy produce may have a mildly feminizing effect, and that this could lead to complications such as gynecomastia (breast development in men), or that it could impact fertility. (2011). The effect was stronger in some men than others, making it unclear whether genetics or metabolism made a difference in lowering PSA levels. 5. Our personalized portal helps you refer your patients and communicate with their MD Anderson care team. Jargin, S. V. (2014). Researchers call for more studies to confirm how genistein works, how it could be used therapeutically, and its bioavailability, or how well the body can absorb it. Tofu is a soy-based food, and there is growing concern over a possible link between soy and breast cancer. Fritz H, Seely D, Flower G, Skidmore B, Fernandes R, Vadeboncoeur S, et al. The exclusion criteria were as follows: 1) experimental study; 2) letters or case reports; 3) articles that provided inadequate data or only information for breast cancer mortality. Soybean products and reduction of breast cancer risk: a case-control study in Japan. "Menopause and Heart Disease." A range of tofu products are available for purchase online. 2018 Jan 4;10(1 Zhang FF et al. Tofu can be helpful for several health concerns:Eating soy foods like tofu, edamame and soy milk has been linked to reduced risk of certain cancers including breast cancer, prostate cancer and gastric cancer. Wu AH, Wan P, Hankin J, Tseng CC, Yu MC, Pike MC. It has been hypothesized that isoflavones protect against breast cancer through competitive binding to estrogen receptors. They have also been reported to reduce some other symptoms of menopause. Soy-based foods are a popular and healthy alternative to meat. All relevant data are within the manuscript and its Supporting Information files. Tofu comes in several different consistencies: Extra firm, firm, soft, or silken. There was no significant heterogeneity (P = 0.221, I2 = 20.9%) after excluding the 2 studies, and the overall association was not materially changed (OR 0.83; 95% CI, 0.760.91). Age, study area, family history of breast cancer, age at menopause, age at first birth, parity, use of exogenous female hormone, smoking, consumption of green leafy vegetables, walking time, body mass index, and total energy intake, Self-administered questionnaire (validated FFQ), Drinking habit, smoking habit, BMI, regular exercise, family history of, Drinking, multivitamin use, number of children, breast feeding, and quintile of carbohydrate intake, dietary factors (quintiles of energy, vitamin E, and folate), Age, body mass index, family history of breast cancer, current use of dietary supplements, education, occupation, smoking, alcohol intake, physical activity, menopausal status, age at, Menopausal status, body mass index, education level, first-degree family history of breast cancer, history of benign breast disease, number of pregnancies, age at menarche, breastfeeding history, total number of mammograms, smoking habit, alcohol consumption, phytoestrogen supplement use, energy intake, fiber intake, Self-administered questionnaire (176 items FFQ), Source of control (in case-control studies), Adjustment for most important confounders. But some consumers shy away from them out of concern about hormones. Investigating the power of music for dementia. Tofu is a nutritious source of protein made from coagulated soy milk. Does Soy Cause Cancer? Dr Greger, Dr Campbell, Dr McDougall - YouTube Several clinical and experimental investigations have suggested that genistein, the predominant isoflavone in soy, has antioxidant properties that may inhibit the growth of cancer cells. Does high soy milk intake reduce prostate cancer incidence? Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. The Galbraith plot suggested that the observed heterogeneity seemed to be explained by Cho et als [16] and Kim et als [15] studies, which had low quality scores (both were 6) and were the studies with the strongest protective relationships. The role of dietary factors in the cause of breast cancer has been extensively investigated, . Adding them to the diet can help, A variety of meat substitutes are available, including tofu, tempeh, and seitan. In some animal studies, rodents that were exposed to high doses of compounds found in soy called isoflavones showed an increased risk of breast cancer. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Safety of soy intake after breast cancer diagnosis. But rodents process soy differently from people, and the same results have not been seen in people. The raw vegan diet is high in raw fruits and vegetables and low in processed foods. Our expert helps you separate the good advice from the food myths. Our 24/7 cancer helpline provides support for people dealing with cancer. positive breast cancer. Published meta-analyses [11, 12, 47] have shown that soy isoflavones intake could reduce the risk of breast cancer. PA and PS play an important role in the functioning of neurones. Link LB, Canchola AJ, Bernstein L, Clarke CA, Stram DO, Ursin G, et al. yogurt. Other dietary sources include kudzu root and potato beans. The pool OR of ten studies showed an inverse relationship with statistical significance in premenopausal women (OR = 0.70; 95% CI, 0.520.87); for postmenopausal women, the pool OR of nine studies were 0.72 (95%CI 0.470.97), which is similar to the OR in premenopausal women. Among the identified articles, nine studies were conducted in Asia [1316, 37, 3941, 43], four in America [38, 42, 44, 45], and one in Germany [46]. When the same group carried out a further small study, involving 65 people over the age of 60 years with Alzheimers, they did not find that soy isoflavines offered any cognitive benefits. This heterogeneity should be taken into account when interpreting the dose-response results. Age, Asian-ethnicity, birthplace, age at menarche, pregnancy, BMI, menopausal status and use of menopausal hormones, smoking history, alcohol intake, physical activity and family history. 2023 The University of Texas MD Anderson Soy isoflavones may help reduce bone loss and increase bone mineral density, especially after menopause. Mor, M. & Rutenberg, D. (2017). For each study, we assigned the midpoint of the tofu intake in each category as the assigned dose, and half the width of the preceding category was used to define the corresponding point for the open-ended categories. official website and that any information you provide is encrypted After screening the titles and abstract, 2629 publications were excluded due to no relevant data, duplicates, reviews, case series, and the remaining 25 were considered as of potential values. Estrogen can fuel certain cancers, like some breast cancers and prostate cancers. A high intake of total soy products, legumes, and sprouts was associated with a reduced risk for colorectal cancer in men and women, although the middle quartiles of intake of total soy products were associated with an elevated risk. However, among the five studies included in the dose-response analysis, two were quintile-based comparisons, one quartile-based, one tertile-based, and one used g/day for each category point. Protein, and particularly soy protein, may enhance renal function, and it could have benefits for people who are undergoing dialysis or kidney transplantation. Solid line represents the estimated odds ratios, and the dotted lines represent the 95% confidence intervals. The pros and cons of phytoestrogens - PMC - National Center for calcium chloride, calcium sulfate), and calcium may serve as a potential regulator in breast cancer cell proliferation [52]. The sensitivity analysis was also conducted by removing one study at a time and analyzing the remaining studies (S2 Fig). However, owing to the limitations of case-control studies, more properly designed prospective studies are warranted to confirm this association. How does soy affect breast cancer? So soy foods cause cancer? | MD Anderson Cancer Center